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University of Pennsylvania researchers analyzed over 400,000 Reddit posts from nearly 70,000 users across five years and found that semaglutide and tirzepatide users are reporting menstrual irregularities and temperature complaints like chills
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Postmenopausal women on the GLP-1 medication tirzepatide (Zepbound) for obesity lost more weight if they were also using menopause hormone therapy, a retrospective cohort study indicated. https://www.medpagetoday.com/endocrinology/menopause/119594
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Wegovy and Hot Flashes: What to Know
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What medications can cause hot flashes?
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Hormone Therapy May Boost Weight Loss on Tirzepatide, A real-world study presented at ENDO 2025 found that menopausal hormone therapy (MHT) significantly enhanced weight loss in postmenopausal women
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Menopause Weight Loss Treatment: Hormone Therapy + Tirzepatide
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