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Discovery of GLP-1–Based Drugs for the Treatment of Obesity
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GLP-1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal. Read
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Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis
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GLP-1 Receptor Agonists #2026Review @NEJM https://www.nejm .org/doi/full/10.1056/NEJMra2500106
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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
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𝗧𝗵𝗲 𝗘𝗳𝗳𝗲𝗰𝘁 𝗼𝗳 𝗚𝗟𝗣-𝟭 𝗥𝗲𝗰𝗲𝗽𝘁𝗼𝗿 𝗔𝗴𝗼𝗻𝗶𝘀𝘁𝘀 𝗼𝗻 𝗚𝗹𝘆𝗰𝗮𝘁𝗲𝗱 𝗛𝗲𝗺𝗼𝗴𝗹𝗼𝗯𝗶𝗻 𝗟𝗲𝘃𝗲𝗹𝘀 Randomized, placebo-controlled trials of the glucagon-like peptide-1 (GLP-1) receptor agonists have provided strong
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In patients with #obesity, incretin-based therapies such as GLP-1 receptor agonists are reported to result in mean weight reductions of approximately 15 to 20% along with additional health benefits, including decreased cardiovascular
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